After being bitten by a genetically altered spider, nerdy high school student Peter Parker is endowed with amazing powers.
121 min.
Sam Raimi
| Tobey Maguire | Spider-Man / Peter Parker |
| Willem Dafoe | Green Goblin / Norman Osborn |
| Kirsten Dunst | Mary Jane Watson |
| James Franco | Harry Osborn |
| Cliff Robertson | Ben Parker |
| J.K. Simmons | J. Jonah Jameson |
| Joe Manganiello | Flash Thompson |
| Gerry Becker | Maximilian Fargas |
| Rosemary Harris | May Parker |
| Bill Nunn | Joseph 'Robbie' Robertson |
| Bruce Campbell | Ring Announcer |
| Stanley Anderson | General Slocum |
| Ron Perkins | Dr. Mendell Stromm |
| Michael Papajohn | Carjacker |
| K. K. Dodds | Simkins |
| Jack Betts | Henry Balkan |
| Elizabeth Banks | Miss Brant |
| Shan Omar Huey | Teacher |
| Lucy Lawless | Punk Rock Girl |
| Robert Kerman | Tugboat Captain |
| Ted Raimi | Hoffman |
| John Paxton | Houseman |
| Octavia Spencer | Check-In Girl |
| Randy Savage | Bone Saw McGraw |
| Jayce Bartok | Subway Guitarist |
| Sara Ramirez | Cop at Carjacking |
| Una Damon | Lab Tour Guide |
| Stan Lee | Man in Fair |